In-depth resistome analysis by targeted metagenomics
نویسندگان
چکیده
منابع مشابه
In-depth resistome analysis by targeted metagenomics
BACKGROUND Antimicrobial resistance is a major global health challenge. Metagenomics allows analyzing the presence and dynamics of "resistomes" (the ensemble of genes encoding antimicrobial resistance in a given microbiome) in disparate microbial ecosystems. However, the low sensitivity and specificity of available metagenomic methods preclude the detection of minority populations (often presen...
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References 1. Keller, P.J., Schmidt, A.D., Wittbrodt, J., and Stelzer, E.H.K. (2008). Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy. Science 322, 1065–1069. 2. Rembold, M., Loosli, F., Adams, R.J., and Wittbrodt, J. (2006). Individual cell migration serves as the driving force for optic vesicle evagination. Science 313, 1130–1134. 3. Faure-André, G., ...
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BACKGROUND Antibiotic-resistant pathogens are challenging treatment of infections worldwide. Urban sewage is potentially a major conduit for dissemination of antibiotic resistance genes into various environmental compartments. However, the diversity and abundance of such genes in wastewater are not well known. METHODS Here, seasonal and geographical distributions of antibiotic resistance gene...
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Improved sampling of diverse environments and advances in the development and application of next-generation sequencing technologies is accelerating the rate at which new metagenomes are produced. Over the past few years, the major challenge associated with metagenomics has shifted from generating to analyzing sequences. Metagenomic analysis includes the identification, and functional and evolu...
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© Journal of Laboratory and Precision Medicine. All rights reserved. J Lab Precis Med 2017;2:29 jlpm.amegroups.com Not since the emergence of enterohemorrhagic E. coli (EHEC) in the 1980s have bacteria gained such attention in the public eye, among food producers, healthcare workers and researchers worldwide. Currently, antimicrobial resistant microorganisms are now recognized as one of the mos...
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ژورنال
عنوان ژورنال: Microbiome
سال: 2018
ISSN: 2049-2618
DOI: 10.1186/s40168-017-0387-y